A fire has engulfed a building in Sydney’s south overnight, destroying several businesses and storage units.

More than 50 firefighters fought the blaze on Princes Highway in Kirrawee at approximately 10pm on Sunday.

7 News report that the fire broke out on the third level, with smoke billowing through the roof.

While a neighbouring McDonald’s store managed to be saved, numerous other businesses at 555 Princes Highway were not so lucky.

No injuries were reported.

Want more? Get more from Kyle & Jackie O!